BIODEGRADATION OF A POLY(ALPHA-AMINO ACID) HYDROGEL .1. INVIVO

被引：59
|
作者：
DICKINSON, HR [1 ]
HILTNER, A [1 ]
GIBBONS, DF [1 ]
ANDERSON, JM [1 ]
机构：
[1] CASE WESTERN RESERVE UNIV,DEPT MACROMOLEC SCI,CLEVELAND,OH 44106
来源：
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH | 1981年 / 15卷 / 04期
关键词：
BIOMEDICAL ENGINEERING - Surgical Implants - ENZYMES AND ENZYME TECHNOLOGY - PROTEINS - Hydrolysis;
D O I：
10.1002/jbm.820150412
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
A new hydrogel material has been prepared by crosslinking a hydrophilic, m nonionic poly(amino acid), poly(2-hydroxyethyl-L-glutamine). The material properties of the hydrogel can be controlled by variation in the crosslink density, and the swelling ratio was found to be a sensitive and convenient method for measuring the extent of in vivo biodegradation of implanted specimens. Degradation of the material was observed only during the first 2 weeks of subcutaneous implantation in rats, and is attributed to hydrolysis by proteolytic enzymes released during the acute and chronic stages of the normal inflammatory response.
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页码：577 / 589
页数：13
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