NOREPINEPHRINE REVERSES N-METHYL-D-ASPARTATE-MEDIATED INHIBITION OF LONG-TERM POTENTIATION IN RAT HIPPOCAMPAL SLICES

被引：19
|
作者：
IZUMI, Y
CLIFFORD, DB
ZORUMSKI, CF
机构：
[1] WASHINGTON UNIV,SCH MED,DEPT PSYCHIAT,4940 AUDUBON AVE,ST LOUIS,MO 63110
[2] WASHINGTON UNIV,SCH MED,DEPT NEUROL,ST LOUIS,MO 63110
[3] WASHINGTON UNIV,SCH MED,DEPT ANAT & NEUROBIOL,ST LOUIS,MO 63110
来源：
NEUROSCIENCE LETTERS | 1992年 / 142卷 / 02期
关键词：
NOREPINEPHRINE; N-METHYL-D-ASPARTATE; LONG-TERM POTENTIATION; METABOTROPIC RECEPTOR; HIPPOCAMPUS;
D O I：
10.1016/0304-3940(92)90364-D
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Application of 1-mu-M N-methyl-D-aspartate (NMDA) either immediately before or following tetanic stimulation inhibits the induction of CA1 hippocampal long-term potentiation (LTP). We have examined the effect of trans-amino-1,3-cyclopentanedicarboxylic acid(ACPD), norepinephrine and acetylcholine on this NMDA-mediated LTP inhibition using extracellular recordings from in vitro rat hippocampal slices. When NMDA is accompanied by 100-mu-M ACPD or 10-mu-M norepinephrine. the block of LTP is overcome. The norepinephrine effect is mimicked by phenylephrine and methoxamine and is blocked by phentolamine and prazosin suggesting the involvement of alpha-1-adrenergic receptors.
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页码：163 / 166
页数：4
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