ANTIULCEROGENIC EFFECTS OF BENZYLPENICILLIN IN ACUTELY STRESSED RATS

被引：0
|
作者：
KALUEV, AV [1 ]
SAMONINA, GE [1 ]
ASHMARIN, IP [1 ]
机构：
[1] MOSCOW MV LOMONOSOV STATE UNIV,DEPT BIOL,CHAIR HUMAN & ANIM PHYSIOL,MOSCOW,RUSSIA
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 1994年 / 118卷 / 08期
关键词：
ULCEROGENESIS; ACUTE STRESS; BENZYLPENICILLIN;
D O I：
10.1007/BF02444437
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
The antibiotic benzylpenicillin was found to produce dose-dependent antiulcerogenic effects in rats when administered immediately before their exposure to acute stress (swimming for 1 h) that led to gastric mucosal ulceration. Such effects were not observed in rats given benzylpenicillin 48 h before stress exposure. The results of this study suggest that in acutely stressed animals benzylpenicillin may activate as yet unidentified mechanisms which afford protection to the gastric mucosa and which are not associated with the longer-lasting antimicrobial effects of this antibiotic.
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页码：818 / 820
页数：3
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