GENE-EXPRESSION DURING OOGENESIS IN MICE

A mouse egg is the end-product of oogenesis - a process initiated during fetal development and completed months later at the time of sperm-egg fusion. Oogenesis includes many important events. Among these are formation of female germ cells, initiation and completion of meiosis, and establishment of a maternal store of materials to support fertilization and preimplantation development. The latter takes place largely during germ cell growth in sexually mature females and involves extensive gene expression. Ribonucleic acid and protein accumulate to unusually high levels during this relatively short phase of oogenesis. Recent studies have demonstrated that establishment of a maternal store of materials in the growing mouse egg is both transcriptionally and translationally regulated. Specific examples of both types of regulation are presented here in the context of gene expression during oogenesis in mice.