Starving PTEN-deficient prostate cancer cells thrive under nutrient stress by scavenging corpses for their supper

被引：6
|
作者：
Jayashankar, Vaishali [1 ]
Finicle, Brendan T. [1 ]
Edinger, Aimee L. [1 ]
机构：
[1] Univ Calif Irvine, Dept Dev & Cell Biol, Irvine, CA 92717 USA
来源：
MOLECULAR & CELLULAR ONCOLOGY | 2018年 / 5卷 / 04期
关键词：
macropinocytosis; nutrient scavenging; prostate cancer; PTEN; PI3K pathway; AMPK; necrosis;
D O I：
10.1080/23723556.2018.1472060
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Our recent work demonstrates that inactivating mutations in phosphatase and tensin homolog (PTEN) are sufficient to drive macropinocytosis in the context of AMP-activated protein kinase (AMPK) activation. Given that blocking macropinocytosis limits PTEN-deficient prostate tumor growth, AMPK or phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K) inhibitors could have therapeutic value in castration-resistant prostate cancer patients, particularly when used in combination with standard of care therapies.
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页数：3
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