EFFECTS OF 3'-DEOXYADENOSINE (CORDYCEPIN) ON THE REPAIR OF X-RAY-INDUCED DNA SINGLE-STRAND AND DOUBLE-STRAND BREAKS IN CHINESE HAMSTER V79 CELLS

Cordycepin/3’-deoxyadenosine/DSB/SSB/DNA repair The ability of cordycepin to inhibit the repair of DNA strand breaks was examined with X-irradiated Chinese hamster V79 cells in log-phase culture. A filter elution technique revealed that 70μM cordycepin did not inhibit the repair of single-strand breaks but inhibited the repair of double-strand breaks. These findings confirmed the fact that the increase in the lethality of cordycepin in X-irradiated cultured mammalian cells was attributable to unrepaired DNA double-strand breaks. © 1990, Journal of Radiation Research Editorial Committee. All rights reserved.