p16(INK4A) expression in invasive laryngeal cancer

被引：20

作者：

Hernandez, Brenda Y. ^{[1
]}

Rahman, Mobeen ^{[2
]}

Lynch, Charles F. ^{[3
]}

Cozen, Wendy ^{[4
,5
,6
]}

Unger, Elizabeth R. ^{[7
,8
]}

Steinau, Martin ^{[7
,8
]}

Thompson, Trevor ^{[9
,10
]}

Saber, Maria Sibug ^{[11
]}

Altekruse, Sean F. ^{[12
]}

Goodman, Marc T. ^{[13
]}

Powers, Amy ^{[14
]}

Lyu, Christopher ^{[15
]}

Saraiya, Mona ^{[16
,17
]}

机构：

[1] Univ Hawaii, Ctr Canc, 701 Ilalo St 239, Honolulu, HI 96813 USA

[2] Univ Hawaii, John A Burns Sch Med, 651 Ilalo St 411E, Honolulu, HI 96813 USA

[3] Univ Iowa, Coll Publ Hlth, Dept Epidemiol, 145 North Riverside Dr 5447 CPHB, Iowa City, IA 52242 USA

[4] Univ Southern Calif, Norris Comprehens Canc Ctr, 1441 Eastlake Ave MC 9175, Los Angeles, CA 90089 USA

[5] Keck Sch Med, Dept Prevent Med, 1441 Eastlake Ave MC 9175, Los Angeles, CA 90089 USA

[6] Keck Sch Med, Dept Pathol, 1441 Eastlake Ave MC 9175, Los Angeles, CA 90089 USA

[7] Ctr Dis Control, Natl Ctr Emerging & Zoonot Infect Dis, Div High Consequence Pathogens & Pathol, Atlanta, GA 30329 USA

[8] Ctr Dis Prevent, Natl Ctr Emerging & Zoonot Infect Dis, Div High Consequence Pathogens & Pathol, Atlanta, GA 30329 USA

[9] Ctr Dis Control, 4770 Buford Highway NE,Mailstop F 76, Atlanta, GA 30341 USA

[10] Ctr Dis Prevent, 4770 Buford Highway NE,Mailstop F 76, Atlanta, GA 30341 USA

[11] Univ Southern Calif, Norris Comprehens Canc Ctr, 1441 Eastlake Ave 4420, Los Angeles, CA 90089 USA

[12] Natl Canc Inst, Surveillance Res Program, 9609 Med Ctr Dr,Room 4E536, Rockville, MD 20850 USA

[13] Cedars Sinai Med Ctr, 8700 Beverly Blvd,Room 1S37, Los Angeles, CA 90048 USA

[14] Queens Med Ctr, Dept Pathol, 1301 Punchbowl St, Honolulu, HI 96813 USA

[15] Battelle Mem Inst, 100 Capitola Dr,Suite 200, Durham, NC 27713 USA

[16] Ctr Dis Control, 4770 Buford Highway NE, Atlanta, GA 30341 USA

[17] Ctr Dis Prevent, 4770 Buford Highway NE, Atlanta, GA 30341 USA

来源：

PAPILLOMAVIRUS RESEARCH | 2016年 / 2卷

关键词：

Larynx; Laryngeal cancer; Human papillomavirus; HPV; P16(INK4A); P16;

D O I：

10.1016/j.pvr.2016.03.001

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We examined p16 expression in tumors from a population-based sample of laryngeal cancer cases diagnosed in the U.S. Samples had been previously genotyped for HPV DNA. Overall, p16 expression was observed in laryngeal tissue from 8 of 101 (7.9%) cases. p16 expression was observed in 2 of 16 (12.5%) cases previously determined to be HPV DNA positive. The two cases dually positive for p16 and HPV DNA were non-keratinizing SCC and papillary SCC tumors that were positive for genotypes 18 and 35/89, respectively. Positivity for p16 and/or HPV DNA was not associated with 5-year survival (log-rank p value =0.55). Our findings support a limited role of HPV in laryngeal carcinogenesis. p16 is not a reliable surrogate for HPV status in laryngeal cancers and is not a predictor of laryngeal cancer survival. (C) 2016 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license http://creativecommons.org/licenses/by/4.0/).

引用

页码：52 / 55

页数：4

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