OPIOID AND NONOPIOID INTERACTIONS IN 2 FORMS OF STRESS-INDUCED ANALGESIA

被引:39
|
作者
GRISEL, JE
FLESHNER, M
WATKINS, LR
MAIER, SF
机构
[1] Department of Psychology, University of Colorado, Boulder, CO 80309
关键词
ANALGESIA; OPIOID-NONOPIOID INTERACTIONS; MORPHINE; NALTREXONE; STRESS; COLD WATER SWIM; SOCIAL DEFEAT;
D O I
10.1016/0091-3057(93)90100-8
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
Stressful environmental events activate endogenous mechanisms of pain inhibition. Under some circumstances the analgesia is blocked by naloxone/naltrexone (''opioid''), while under others it is not (''nonopioid''). The existence of these two categories of analgesia leads to the question of how they are related. In a collateral inhibition model proposed by Kirshgessner, Bodnar, and Pasternak (1982), opiate and nonopiate mechanisms were viewed as acting in a mutually inhibitory fashion. In the present experiments, rats were exposed to either of two environmental stressors that produce a nonopioid stress-induced analgesia (SIA) following injections of the opiate antagonist naltrexone or agonist morphine. In the presence of naltrexone, SIA produced by either cold water swim (CWS) or social defeat was enhanced. These same SIAs were found to attenuate the analgesic effect of morphine, demonstrating that an activation of opioid systems can inhibit nonopioid analgesias. These results support an inhibitory interaction of opioid and nonopioid mechanisms in some forms of stress-induced analgesia.
引用
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页码:161 / 172
页数:12
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