RIBONUCLEOTIDE REDUCTASE TARGETS FOR CHEMOTHERAPY - MECHANISTIC ASPECTS AND BIOLOGICALLY-ACTIVE AGENTS

被引：22
|
作者：
ROBINS, MJ
SAMANO, MC
SAMANO, V
机构：
[1] Department of Chemistry and Biochemistry, Brigham Young University, 84602, Provo, UT
[2] Burroughs Wellcome Co., Research Triangle Park, NC
来源：
NUCLEOSIDES & NUCLEOTIDES | 1995年 / 14卷 / 3-5期
关键词：
D O I：
10.1080/15257779508012411
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Ribonucleotide reductases are essential for the de novo biosynthesis of the 2'-deoxynucleotide components of DNA. These enzymes have complex cofactors and execute novel chemistry involving C2' via radical abstraction of H3'. Mechanistic aspects of these transformations and selected nucleotide analogues that cause mechanism-based inactivation of ribonucleotide reductases are discussed.
引用
收藏
页码：485 / 493
页数：9
相关论文
共 50 条
  • [1] CONTROLLED RELEASE OF BIOLOGICALLY-ACTIVE AGENTS
    YOLLES, S
    LEST, T
    WARD, L
    BOETTNER, F
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1976, : 85 - 85
  • [2] CONTROLLED RELEASE OF BIOLOGICALLY-ACTIVE AGENTS
    YOLLES, S
    ACTA PHARMACEUTICA SUECICA, 1976, 13 : 32 - 32
  • [3] CONTROLLED RELEASE OF BIOLOGICALLY-ACTIVE AGENTS
    YOLLES, S
    LEAFE, T
    SARTORI, M
    TORKELSON, M
    WARD, L
    BOETTNER, F
    ACS SYMPOSIUM SERIES, 1976, (33): : 123 - 134
  • [4] STRATEGY LEVEL REACTIONS AND BIOLOGICALLY-ACTIVE TARGETS
    WENDER, PA
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1988, 195 : 72 - ORGN
  • [5] IMIDAZOLE AND ITS DERIVATIVES AS BIOLOGICALLY-ACTIVE AGENTS
    SHAIMARDANOVA, GS
    KAMBURG, RA
    YEVSTIGNEYEVA, RP
    SERGEYEVA, NV
    KHIMIKO-FARMATSEVTICHESKII ZHURNAL, 1992, 26 (03): : 31 - 38
  • [6] BIOLOGICALLY-ACTIVE FLUIDIZED-BEDS - MECHANISTIC CONSIDERATIONS
    NGIAN, KF
    MARTIN, WRB
    BIOTECHNOLOGY AND BIOENGINEERING, 1980, 22 (05) : 1007 - 1014
  • [7] TOPOLOGICAL ASPECTS IN QSAR FOR BIOLOGICALLY-ACTIVE MOLECULES
    BALABAN, AT
    NICULESCUDUVAZ, I
    SIMON, Z
    ACTA PHARMACEUTICA JUGOSLAVICA, 1987, 37 (01): : 7 - 36
  • [8] BIOLOGICALLY-ACTIVE POLYMER - TARGETING POLYMERIC ANTITUMOR AGENTS
    HAN, MJ
    CHOI, KB
    KIM, KH
    HAHN, BS
    LEE, WY
    MAKROMOLEKULARE CHEMIE-MACROMOLECULAR SYMPOSIA, 1990, 33 : 301 - 309
  • [9] BIOLOGICALLY-ACTIVE MICROBIAL COMPOUNDS AS USEFUL AGENTS IN AGRICULTURE
    GROGER, D
    WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY, 1992, 8 : 111 - 114
  • [10] SYNTHESIS OF NEW THIAZOLIDINONE DERIVATIVES AS BIOLOGICALLY-ACTIVE AGENTS
    GUPTA, AKS
    PANDEY, AK
    JOURNAL OF THE INDIAN CHEMICAL SOCIETY, 1988, 65 (02) : 142 - 144
12345