PERINATAL HYPOXIA SUPPRESSES IMMUNE-RESPONSE OF ADULT-RATS

被引：0
|
作者：
VIZEK, M [1 ]
DOSTAL, M [1 ]
SOUKUPOVA, D [1 ]
机构：
[1] CZECHOSLOVAK ACAD SCI, INST EXPTL MED, CS-11142 PRAGUE 1, CZECHOSLOVAKIA
来源：
PHYSIOLOGICAL RESEARCH | 1993年 / 42卷 / 03期
关键词：
NORMOBARIC HYPOXIA; DEVELOPMENT; RAT; IMMUNE RESPONSE;
D O I：
暂无
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
We tested the effect of perinatal (one week prenatal and one week postnatal) normobaric hypoxia on the immune response of rats in their 9th week of life. We found that perinatally hypoxic rats produced less serum antibodies after sequential immunization with ovalbumin and sheep red blood cells. Also phagocytosis of HEMA microparticles by neutrophil leukocytes from perinatally hypoxic rats was depressed as well as the oxidative burst of their peritoneal macrophages and neutrophils. These results demonstrate that perinatal hypoxia has an important effect on the immune system of the rat.
引用
收藏
页码：201 / 205
页数：5
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