INTEGRATING CHROMOSOME STRUCTURE WITH FUNCTION

被引：55
|
作者：
RATTNER, JB
机构：
[1] Department of Anatomy and Medical Biochemistry, University of Calgary, Calgary, T2N 1N4, Alberta
来源：
CHROMOSOMA | 1992年 / 101卷 / 5-6期
关键词：
D O I：
10.1007/BF00346003
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Historically, the metaphase chromosome and its architecture has been viewed as the ultimate representation of a non-functional inactive chromatin state. Recent studies of centromere (kinetochore) function in concert with studies of the placement and function of several classes of chromosomal proteins now call for a reevaluation of this view. In this article a model of chromosome structure with functional correlates is presented. Evidence for the existence of a functional chromosomal region, the "Surface Domain" is discussed.
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页码：259 / 264
页数：6
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