Handedness- and Brain Size-Related Efficiency Differences in Small-World Brain Networks: A Resting-State Functional Magnetic Resonance Imaging Study

被引:8
|
作者
Li, Meiling [1 ]
Wang, Junping [2 ]
Liu, Feng [1 ]
Chen, Heng [1 ]
Lu, Fengmei [1 ]
Wu, Guorong [1 ]
Yu, Chunshui [2 ]
Chen, Huafu [1 ]
机构
[1] Univ Elect Sci & Technol China, Sch Life Sci & Technol, Minist Educ, Key Lab Neuroinformat, Chengdu 610054, Sichuan, Peoples R China
[2] Tianjin Med Univ Gen Hosp, Dept Radiol, Tianjin, Peoples R China
基金
高等学校博士学科点专项科研基金;
关键词
brain size; efficiency; functional connectivity; handedness; small-world;
D O I
10.1089/brain.2014.0291
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The human brain has been described as a complex network, which integrates information with high efficiency. However, the relationships between the efficiency of human brain functional networks and handedness and brain size remain unclear. Twenty-one left-handed and 32 right-handed healthy subjects underwent a resting-state functional magnetic resonance imaging scan. The whole brain functional networks were constructed by thresholding Pearson correlation matrices of 90 cortical and subcortical regions. Graph theory-based methods were employed to further analyze their topological properties. As expected, all participants demonstrated small-world topology, suggesting a highly efficient topological structure. Furthermore, we found that smaller brains showed higher local efficiency, whereas larger brains showed higher global efficiency, reflecting a suitable efficiency balance between local specialization and global integration of brain functional activity. Compared with right-handers, significant alterations in nodal efficiency were revealed in left-handers, involving the anterior and median cingulate gyms, middle temporal gyms, angular gyms, and amygdala. Our findings indicated that the functional network organization in the human brain was associated with handedness and brain size.
引用
收藏
页码:259 / 265
页数:7
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