DIRECT MEASUREMENT OF THE TRANSPORT-PROPERTIES OF A SINGLE DNA MOLECULE

被引：93
|
作者：
WIRTZ, D
机构：
[1] Department of Chemical Engineering, Johns Hopkins University, Baltimore, MD 21218
来源：
PHYSICAL REVIEW LETTERS | 1995年 / 75卷 / 12期
关键词：
D O I：
10.1103/PhysRevLett.75.2436
中图分类号：
O4 [物理学];
学科分类号：
0702 ;
摘要：
A fluorescently labeled DNA molecule is end tethered to a small magnetic bead and pulled by a calibrated magnetic force through a solution of unlabeled DNA molecules to monitor the transport coefficients of the chain. From the force velocity diagram F-V, we report the first direct measurement of the friction coefficient zeta = F/V of a single DNA molecule. zeta is found to be highly velocity dependent due to sharp conformational transitions for increasing velocities in agreement with a recent model by Ajdari et al.
引用
收藏
页码：2436 / 2439
页数：4
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