(2S,3R,4S)-4-(1,1-DIMETHYLETHOXYCARBONYLAMINO)-2,3-EPOXY-5-PHENYLPENTANOIC ACID ETHYL-ESTER

被引：1
|
作者：
WEBER, HP [1 ]
SCHOLZ, D [1 ]
SCHMIDT, H [1 ]
GSTACH, H [1 ]
机构：
[1] SANDOZ GMBH,FORSCHUNGSINST,A-1235 VIENNA,AUSTRIA
来源：
ACTA CRYSTALLOGRAPHICA SECTION C-CRYSTAL STRUCTURE COMMUNICATIONS | 1995年 / 51卷
关键词：
D O I：
10.1107/S0108270194010656
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The X-ray analysis of the title compound [alternative name: ethyl 4-(tert-butoxycarboxamido)-2,3-epoxy-5-phenylpentanoate, C18H25NO5, was performed in order to prove the structure of the synthetic product with respect to the existence of a trans epoxide and to determine the relative configurations of atoms C(2) (S) and C(3) (R) with respect to the known chirality of atom C(4) (S). There are no unusual structural features in the crystal although the torsion angles between the epoxide and the carboxamido groups are noteworthy.
引用
收藏
页码：477 / 479
页数：3
相关论文
共 50 条
  • [1] (3R,4S,5S)-5-BENZYL-4-HYDROXY-3-[1(S)-(1,1-DIMETHYLETHOXYCARBONYLAMINO)-2-PHENYL-ETHYL]PYRROLIDIN-2-ONE
    WEBER, HP
    ETTMAYER, P
    HUBNER, M
    GSTACH, H
    ACTA CRYSTALLOGRAPHICA SECTION C-CRYSTAL STRUCTURE COMMUNICATIONS, 1995, 51 : 2139 - 2141
  • [2] Synthesis of (2S,3R,4S),(2S,3S,4R)-epoxyprolines and aminohydroxyprolines
    Robinson, JK
    Lee, V
    Claridge, TDW
    Baldwin, JE
    Schofield, CJ
    TETRAHEDRON, 1998, 54 (5-6) : 981 - 996
  • [3] (2S*,3R*,4S*,5R*)-3-(S*-1-Benzyloxyethyl)-4-methyl-4-nitro-5-phenylproline methyl ester
    Linden, A
    Ayerbe, M
    Arrieta, A
    Zubia, A
    Vivanco, S
    Erquicia, E
    Aldaba, E
    Cossío, FP
    Lecea, B
    ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2001, 57 : O1123 - O1125
  • [4] ENANTIOSPECIFIC SYNTHESES OF 2S,3R,4R,5S-TRIHYDROXYPIPECOLIC ACID, 2R,3R,4R,5S-TRIHYDROXYPIPECOLIC ACID, 2S,4S,5S-DIHYDROXYPIPECOLIC ACID, AND BULGECININE FROM DEUTERIUM-GLUCURONOLACTONE
    BASHYAL, BP
    CHOW, HF
    FLEET, GWJ
    TETRAHEDRON LETTERS, 1986, 27 (27) : 3205 - 3208
  • [5] SELECTIVE-INHIBITION OF GAMMA-AMINOBUTYRIC-ACID AMINOTRANSFERASE BY (3R,4R),(3S,4S)-4-AMINO-5-FLUORO-3-PHENYLPENTANOIC AND (3R,4S),(3S,4R)-4-AMINO-5-FLUORO-3-PHENYLPENTANOIC ACIDS
    SILVERMAN, RB
    NANAVATI, SM
    JOURNAL OF MEDICINAL CHEMISTRY, 1990, 33 (03) : 931 - 936
  • [6] (1R*,2S*,3R*,4S*)-N-(1-Naphthyl)-5-norbornene-2,3-dicarboximide
    Tian, De-Mei
    Xiong, Chuan-Xi
    Dong, Li-Jie
    ACTA CRYSTALLOGRAPHICA SECTION E-CRYSTALLOGRAPHIC COMMUNICATIONS, 2007, 63 : O2393 - O2394
  • [7] 2S,3R,4R,5S)-3,4,5-trihydroxypipecolic acid dihydrate [(2S,3R,4R,5S)-3,4,5-tri-hydroxypiperidine-2-carboxylic acid dihydrate]
    Booth, Kathrine V.
    Jenkinson, Sarah F.
    Watkin, David J.
    Sharp, Hazel
    Jones, Paul Wyn
    Nash, Robert J.
    Fleet, George W. J.
    ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2007, 63 : O3783 - U2810
  • [8] (3R,4S,5S)-4-hydroxy-3-methyl-5-[(2S,3R)-3-methylpent-4-en-2-yl] tetrahydrofuran-2-one
    Becker, Annika
    Schuermann, Markus
    Preut, Hans
    Hiersemann, Martin
    ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2008, 64 : O1517 - U2536
  • [9] NOVEL SYNTHESIS OF (2S, 3R, 4S)-4-AMINO-5-CYCLOHEXYL-1-MORPHOLINO-2,3-PENTANEDIOL AND (2S, 3R, 4S)-2-AMINO-1-CYCLOHEXYL-6-METHYL-3,4-HEPTANEDIOL, THE C-TERMINAL COMPONENTS OF RENIN INHIBITORS
    KOBAYASHI, Y
    NAKATANI, K
    ITO, Y
    TERASHIMA, S
    CHEMISTRY LETTERS, 1990, (09) : 1709 - 1710
  • [10] Diastereoselective synthesis of (1S,2S,3R,4R) and (1R,2S,3R,4S)-bicyclo[2.2.1]hept-2-amino-2,3-dicarboxylic acids: New conformationally-constrained (S)-aspartic acid analogues
    Bunuel, E
    Cativiela, C
    DiazdeVillegas, MD
    TETRAHEDRON-ASYMMETRY, 1996, 7 (05) : 1521 - 1528
12345