THE MOBILIZATION OF PRIMITIVE HEMATOPOIETIC PROGENITORS INTO THE PERIPHERAL-BLOOD

被引:0
|
作者
SIMMONS, PJ [1 ]
LEAVESLEY, DI [1 ]
LEVESQUE, JP [1 ]
SWART, BW [1 ]
HAYLOCK, DN [1 ]
TO, LB [1 ]
ASHMAN, LK [1 ]
JUTTNER, CA [1 ]
机构
[1] CNRS, VILLEJUIF, FRANCE
关键词
MOBILIZATION; TRANSPLANTATION; HEMATOPOIETIC PROGENITORS; CD34(+) CELLS; BONE MARROW; PERIPHERAL BLOOD; CELL ADHESION; CYTOKINES; C-KIT; EXTRACELLULAR MATRIX;
D O I
暂无
中图分类号
Q813 [细胞工程];
学科分类号
摘要
There is considerable interest in the use of peripheral blood progenitor cells (PBPC) for hemopoietic rescue following high dose chemotherapy. Current regimens mobilize CD34(+) with variable efficacy and there remains considerable empiricism in the design of these regimens. Some involve myelosuppression, some the administration of various cytokines alone or in combination, while a combination of chemotherapy and cytokines is employed in others. Certain protocols result in mobilization within one week while in others, maximal PBPC levels occur only after several weeks. Thus, procedures required for optimal mobilization of PBPC remain to be defined. An understanding of the mechanisms responsible for mobilization may lead to the development of improved mobilization strategies. Herein we review data that explore the mechanisms involved in the mobilization of PBPC in man. These data demonstrate that mobilization is associated with marked changes in the expression and function of cell adhesion molecules (CAMs) on hemopoietic progenitor cells (HPC), suggesting that the release of HPC into the blood involves a perturbation of the adhesive interactions between these cells and the marrow stroma that, in steady-state conditions, serve to restrict WC to the bone marrow. Downregulation of c-kit is invariably associated with successful mobilization which, when combined with data from in vitro studies, implies a key role for stem cell factor (SCF) as an orchestrator of mobilization.
引用
收藏
页码:187 / 202
页数:16
相关论文
共 50 条
  • [1] FACTORS AFFECTING THE MOBILIZATION OF PRIMITIVE AND COMMITTED HEMATOPOIETIC PROGENITORS INTO THE PERIPHERAL-BLOOD OF CANCER-PATIENTS
    SCHNEIDER, JG
    CROWN, JP
    WASSERHEIT, C
    KRITZ, A
    WONG, G
    REICH, L
    NORTON, L
    MOORE, MAS
    BONE MARROW TRANSPLANTATION, 1994, 14 (06) : 877 - 884
  • [2] PIXY321 MOBILIZATION OF HEMATOPOIETIC PROGENITORS FOR PERIPHERAL-BLOOD STEM-CELL TRANSPLANTS
    MURPHY, BO
    JACKSON, JD
    BISHOP, MR
    WARKENTIN, PI
    KESSINGER, A
    EXPERIMENTAL HEMATOLOGY, 1994, 22 (08) : 704 - 704
  • [3] DURABILITY OF HEMATOPOIESIS FOLLOWING AUTOGRAFTING WITH PERIPHERAL-BLOOD HEMATOPOIETIC PROGENITORS
    SIENA, S
    BREGNI, M
    DINICOLA, M
    RAVAGNANI, F
    PECCATORI, F
    GANDOLA, L
    LOMBARDI, F
    TARELLA, C
    BONADONNA, G
    GIANNI, AM
    ANNALS OF ONCOLOGY, 1994, 5 (10) : 935 - 941
  • [4] PRIMITIVE HEMATOPOIETIC PROGENITOR CELLS ARE PRESENT IN PERIPHERAL-BLOOD AUTOGRAFTS
    TONG, J
    GIANNI, AM
    SIENA, S
    SROUR, EF
    BREGNI, M
    HOFFMAN, R
    BLOOD CELLS, 1994, 20 (2-3): : 351 - 363
  • [5] PHARMACOLOGICAL MOBILIZATION OF HEMATOPOIETIC PROGENITOR CELLS IN HUMAN PERIPHERAL-BLOOD
    BERARDI, A
    GERACI, L
    QUAGLIETTA, AM
    DIBARTOLOMEO, G
    DRAGANI, A
    HAEMATOLOGICA, 1990, 75 : 15 - 17
  • [6] Mobilization and selection of peripheral blood hematopoietic progenitors in children with systemic sclerosis
    Locatelli, F
    Perotti, C
    Torretta, L
    Maccario, R
    Montagna, D
    Ravelli, A
    Giorgiani, G
    De Benedetti, F
    Giraldi, E
    Magnani, ML
    De Stefano, P
    Martini, A
    HAEMATOLOGICA, 1999, 84 (09) : 839 - 843
  • [7] CHARACTERIZATION OF PRIMITIVE HEMATOPOIETIC-CELLS IN NORMAL HUMAN PERIPHERAL-BLOOD
    UDOMSAKDI, C
    LANSDORP, PM
    HOGGE, DE
    REID, DS
    EAVES, AC
    EAVES, CJ
    BLOOD, 1992, 80 (10) : 2513 - 2521
  • [8] POLYCLONAL PRIMITIVE HEMATOPOIETIC PROGENITORS CAN BE DETECTED IN MOBILIZED PERIPHERAL-BLOOD FROM PATIENTS WITH HIGH-RISK MYELODYSPLASTIC SYNDROMES
    DELFORGE, M
    DEMUYNCK, H
    VANDENBERGHE, P
    VERHOEF, G
    ZACHEE, P
    VANDUPPEN, V
    MARIJNEN, P
    VANDENBERGHE, H
    BOOGAERTS, MA
    BLOOD, 1995, 86 (10) : 3660 - 3667
  • [9] ALLOGENEIC TRANSPLANTATION WITH PERIPHERAL-BLOOD HEMATOPOIETIC PROGENITORS MOBILIZED WITH G-CSF
    LAPORTE, JP
    LESAGE, S
    DOUAY, L
    LOPEZ, M
    ISNARD, F
    NOROL, F
    NAJMAN, A
    GORIN, NC
    BLOOD, 1994, 84 (10) : A90 - A90
  • [10] PREVALENCE OF THE PRIMITIVE MEGAKARYOCYTE PROGENITORS (BFU-MEG) IN ADULT HUMAN PERIPHERAL-BLOOD
    ZAULI, G
    VITALE, L
    BRUNELLI, MA
    BAGNARA, GP
    EXPERIMENTAL HEMATOLOGY, 1992, 20 (07) : 850 - 854