EPIDERMAL GROWTH-FACTOR STIMULATES THYROTROPIN SECRETION IN THE RAT

被引:21
|
作者
ALTSCHULER, LR
PARISI, MN
CAGEAO, LF
CHIOCCHIO, SR
FERNANDEZPOL, JA
ZANINOVICH, AA
机构
[1] HOSP CLIN BUENOS AIRES,CONCIET,CC 29,SUCURSAL 53,RA-1453 BUENOS AIRES,ARGENTINA
[2] INST NEUROBIOL,BUENOS AIRES,ARGENTINA
[3] DEPT VET ADM MED CTR,ST LOUIS,MO
[4] ST LOUIS UNIV,DEPT MED,DIV NUCL MED,ST LOUIS,MO 63103
关键词
EGF; HYPOPHYSIS; THYROTROPIN; THYROID; GROWTH FACTORS;
D O I
10.1159/000126337
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The present work studied the effects of epidermal growth factor (EGF) on the release of thyrotropin (TSH) and prolactin (PRL) from perifused pituitary glands of 200-gram male Wistar rats. Each pituitary gland, cut into halves, was placed in a chamber of a perifusion system connected to a peristaltic pump which conveyed the perifusion medium (Medium 199, pH 7.3, Gibco, USA) from a reservoir to a chamber at a flow rate of 100 mul/min. Each tightly closed chamber contained one pituitary gland and 600 mul medium and it was placed in a water bath at 37-degrees-C throughout the experiment. One milliliter samples of effluent were collected every 10 min for 60 min to obtain baseline values of TSH and PRL. Thereafter, TSH-releasing hormone (TRH) 10(-8) M or EGF (10(-11), 10(-10), 10(-9) or 10(-8) M) were added to individual chambers and the 10-min sampling of effluent continued for 60 min. EGF 10(-11) M elicited no TSH response, but 10(-10) and 10(-9) M doses induced significant increases in TSH secretion (p < 0.01) with a peak at 10 min after addition of EGF. In another experiment, EGF 10(-8) M or TRH 10(-8) M significantly elevated TSH secretion (p < 0.0 1). However, TRH, but not EGF, stimulated PRL secretion (p < 0.0 1). In the in vivo studies, the intravenous administration of EGF 10(-5) M or TRH 10(-5) M both induced significant elevation of TSH release at 10 min after the injection (p < 0.02 for EGF and p < 0.0 1 for TRH). In summary, EGF stimulated TSH secretion from rat pituitary glands in vitro and in vivo, in a magnitude comparable to that of equimolar doses of TRH.
引用
收藏
页码:23 / 27
页数:5
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