POSITRON EMISSION TOMOGRAPHY STUDIES OF BRAIN RECEPTORS

被引：15
|
作者：
MAZIERE, B
MAZIERE, M
机构：
[1] Service Hospitalier Frédéric Joliot, Commissariat à l'Énergie Atomique, Orsay
来源：
FUNDAMENTAL & CLINICAL PHARMACOLOGY | 1991年 / 5卷 / 01期
关键词：
POSITRON EMISSION TOMOGRAPHY (PET); DOPAMINERGIC RECEPTORS; 5; HT; OPIATE; BENZODIAZEPINE; CHOLINERGIC RECEPTORS;
D O I：
10.1111/j.1472-8206.1991.tb00702.x
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Probing the regional distribution and affinity of receptors in the brain, in vivo, in human and non human primates has become possible with the use of selective ligands labelled with positron emitting radionuclides and positron emission tomography (PET). After describing the techniques used in positron emission tomography to characterize a ligand receptor binding and discussing the choice of the label and the limitations and complexities of the in vivo approach, the results obtained in the PET studies of various neurotransmission systems: dopaminergic, opiate, benzodiazepine, serotonin and cholinergic systems are reviewed.
引用
收藏
页码：61 / 91
页数：31
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