Correlation of serum chromium, zinc, magnesium and SOD levels with HbA1c in type 2 diabetes: A cross sectional analysis

The loss of dynamic integrity between homoeostasis of free radicals and antioxidants causes the development of complications like retinopathy, nephropathy, neuropathy, atherosclerosis and cardiovascular diseases in T2DM. Aims and Objectives: To assess the concentrations of serum chromium, zinc, magnesium and SOD in subjects of T2DM and control and to investigate the effect of these variables versus HbA1c. Results: Insignificant difference (P = 0.493) was reported in age (50 +/- 4.7 year compared with 50 +/- 7.2 year), while body mass Index (23 +/- 2 kg/m(2) compared with 26 +/- 4.5 kg/m(2)) between the T2DM subjects and control subject showed significant difference (<0.0001). Inverse Pearson correlation coefficient, r (-0.376), (-0.689), (-0.05), (-0.05), (-0.40), (-0.14), (-0.342) and (-0.548) were established when HbA1c of control and T2DM patients were compared with control and T2DM patients of serum Cr, Zn, Mg and SOD variables in that order. The overall "p"-value demonstrated highly significant result at p < 0.0001 between the T2DM subjects and controls. Conclusion: Strong association between serum chromium and SOD in relation to HbA1c in this study gives a strong point that these variables could be used as markers of cell injury with the intention in further part of life en route to progressive complications in T2DM. (C) 2015 Diabetes India. Published by Elsevier Ltd. All rights reserved.