AMBIENT, BIOLOGICAL, AND BIOLOGICAL EFFECT MONITORING OF EXPOSURE TO POLYCYCLIC AROMATIC-HYDROCARBONS (PAHS)

被引：24
|
作者：
HATJIAN, BA [1 ]
EDWARDS, JW [1 ]
HARRISON, J [1 ]
WILLIAMS, FM [1 ]
BLAIN, PG [1 ]
机构：
[1] FLINDERS UNIV S AUSTRALIA,SCH MED,ENVIRONM HLTH UNIT,ADELAIDE,SA 5001,AUSTRALIA
来源：
TOXICOLOGY LETTERS | 1995年 / 77卷 / 1-3期
关键词：
AMBIENT MONITORING; BIOLOGICAL MONITORING; BIOLOGICAL EFFECT MONITORING; PAHS; OCCUPATIONAL EXPOSURE;
D O I：
10.1016/0378-4274(95)03307-6
中图分类号：
R99 [毒物学（毒理学）];
学科分类号：
100405 ;
摘要：
A novel strategy was utilised to assess the risk to health from exposure to polycyclic aromatic hydrocarbons (PAHs). Ambient monitoring was carried out by personal sampling. Urinary thioethers (UTh) and urinary 1-hydroxypyrene (1-HP) were utilised for biological monitoring. Urinary d-glucaric acid (UDGA) and sister chromatid exchange (SCE) in peripheral blood lymphocytes were used as biological effect markers. The population was categorised into exposed and control groups according to the external dose of PAHs. The excretion of 1-HP in the controls over the 3-day period showed a relatively stable baseline, while the exposed showed a significant increase over the same period of time. SCE frequency in the exposed population was significantly different from controls.
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页码：271 / 279
页数：9
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