Schizophrenia is a psychotic disorder that is chronic and always had a relapse. This study aims to determine the factors associated with the frequency of relapse in patients with schizophrenia in Mental Hospital Tampan, Riau Province 2012. The research design was cross sectional study, with 50 samples of Schizophrenia patient's family who visited in Polyclinic of Mental Hospital Tampan. Data analysis was performed by univariate, bivariate with correlation, simple linear regression, and t-test, multivariate by multiple linear regression tests. The results obtained that the variables associated to the frequency of relapse in patients with schizophrenia are family's knowledge, family's emotional expression. Family's knowledge has the biggest effect with beta coefficient is - 0.461. Confounding variable are family's attitude, family's support, and the obedience of taking medicine. R-2 score is 68.7%. The family was suggested to increase the knowledge by following the counseling and follow the caring process while the patient in mental hospital, so that families get information in dealing skizophrenia patient. Family emotional expression that is not excessive, so the frequency of relapse in patients with schizophrenia was decreased.