MEDIAL PREOPTIC ALPHA-2-ADRENOCEPTORS IN THE REGULATION OF SLEEP-WAKEFULNESS

被引：17
|
作者：
RAMESH, V [1 ]
KUMAR, VM [1 ]
JOHN, J [1 ]
MALLICK, H [1 ]
机构：
[1] ALL INDIA INST MED SCI,DEPT PHYSIOL,NEW DELHI 110029,INDIA
来源：
PHYSIOLOGY & BEHAVIOR | 1995年 / 57卷 / 01期
关键词：
ALPHA(2)-ADRENOCEPTOR; YOHIMBINE; CLONIDINE; SLEEP; WAKEFULNESS; MEDIAL PREOPTIC AREA; RATS;
D O I：
10.1016/0031-9384(94)00297-I
中图分类号：
B84 [心理学];
学科分类号：
04 ; 0402 ;
摘要：
Adrenergic alpha(2) agonist (clonidine) and its antagonist (yohimbine) were locally applied to the medial preoptic area (mPOA), to find out the role of alpha(2) receptors at this brain region in the regulation of sleep-wakefulness. Clonidine produced arousal, whereas yohimbine induced sleep in freely moving animals. Behavioural arousal produced by clonidine administration was accompanied by EEG synchronization. The alpha(2) receptors as the probable site of action of externally applied norepinephrine (NE), is discussed.
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页码：171 / 175
页数：5
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