SPECIALIZED LOCALIZATION OF P-GLYCOPROTEIN RECOGNIZED BY MRK 16 MONOCLONAL-ANTIBODY IN ENDOTHELIAL-CELLS OF THE BRAIN AND THE SPINAL-CORD

被引：93

作者：

SUGAWARA, I

HAMADA, H

TSURUO, T

MORI, S

机构：

[1] JAPANESE FDN CANC RES,CTR CANC CHEMOTHERAPY,TOSHIMA KU,TOKYO 170,JAPAN

[2] UNIV TOKYO,INST APPL MICROBIOL,BUNKYO KU,TOKYO 113,JAPAN

来源：

JAPANESE JOURNAL OF CANCER RESEARCH | 1990年 / 81卷 / 08期

关键词：

Brain; Endothelial cell; MRK; 16; P‐glycoprotein; Spinal cord;

D O I：

10.1111/j.1349-7006.1990.tb02636.x

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

This communication describes the cellular and ultrastructural localization in the central nervous system of P‐glycoprotein (P‐GP) recognized by a murine monoclonal antibody, MRK 16. At the ultrastructural level P‐GP was strictly confined to the luminal surface of the endothelial cells which comprise the capillary vessels of the brain and the spinal cord. No P‐GP was found in the endothelial cells of other organs. Our findings may be useful as a means to define the blood‐brain barrier, and they imply that the blood‐brain barrier is anatomically characterized by the presence of intercellular tight junctions between continuous nonfenestrated endothelial cells. Copyright © 1990, Wiley Blackwell. All rights reserved

引用

页码：727 / 730

页数：4

共 34 条

[1] FURTHER CHARACTERIZATION OF THE HUMAN ADRENAL-DERIVED P-GLYCOPROTEIN RECOGNIZED BY MONOCLONAL-ANTIBODY MRK-16 REACTING WITH ONLY HUMAN P-GLYCOPROTEIN
SUGAWARA, I
HAMADA, H
NAKAHAMA, M
OKAMOTO, S
TSURUO, T
MORI, S
[J]. JAPANESE JOURNAL OF CANCER RESEARCH, 1989, 80 (12): : 1199 - 1205
[2] TOPOLOGY OF P-GLYCOPROTEIN AS DETERMINED BY EPITOPE MAPPING OF MRK-16 MONOCLONAL-ANTIBODY
GEORGES, E
TSURUO, T
LING, V
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1993, 268 (03) : 1792 - 1798
[3] TISSUE DISTRIBUTION OF P-GLYCOPROTEIN ENCODED BY A MULTIDRUG-RESISTANT GENE AS REVEALED BY A MONOCLONAL-ANTIBODY, MRK-16
SUGAWARA, I
KATAOKA, I
MORISHITA, Y
HAMADA, H
TSURUO, T
ITOYAMA, S
MORI, S
[J]. CANCER RESEARCH, 1988, 48 (07) : 1926 - 1929
[4] QUANTITATION OF P-GLYCOPROTEIN RECEPTOR EXPRESSION INVIVO WITH I-125 MRK-16 MONOCLONAL-ANTIBODY (MAB)
SCOTT, AM
ROSA, E
CARMICHAEL, N
FINN, RD
DIVGI, CR
BIEDLER, JL
TSURUO, T
MEHTA, BM
KALAIGIAN, H
LARSON, SM
[J]. JOURNAL OF NUCLEAR MEDICINE, 1993, 34 (05) : P114 - P114
[5] ENHANCED EXPRESSION BY THE BRAIN MATRIX OF P-GLYCOPROTEIN IN BRAIN CAPILLARY ENDOTHELIAL-CELLS
TATSUTA, T
NAITO, M
MIKAMI, K
TSURUO, T
[J]. CELL GROWTH & DIFFERENTIATION, 1994, 5 (10): : 1145 - 1152
[6] ULTRASTRUCTURAL-LOCALIZATION OF P-GLYCOPROTEIN ON CAPILLARY ENDOTHELIAL-CELLS IN HUMAN GLIOMAS
TANAKA, Y
ABE, Y
TSUGU, A
TAKAMIYA, Y
AKATSUKA, A
TSURUO, T
YAMAZAKI, H
UEYAMA, Y
SATO, O
TAMAOKI, N
NAKAMURA, M
[J]. VIRCHOWS ARCHIV-AN INTERNATIONAL JOURNAL OF PATHOLOGY, 1994, 425 (02): : 133 - 138
[7] BIOCHEMICAL-CHARACTERIZATION AND LOCALIZATION IN BRAIN OF A HUMAN BRAIN-LEUKOCYTE MEMBRANE GLYCOPROTEIN RECOGNIZED BY A MONOCLONAL-ANTIBODY
MCKENZIE, JL
DALCHAU, R
FABRE, JW
[J]. JOURNAL OF NEUROCHEMISTRY, 1982, 39 (05) : 1461 - 1466
[8] EFFECT OF TREATMENT WITH CYCLOSPORINE-A AND THE P-GLYCOPROTEIN MONOCLONAL-ANTIBODY MRK-16 ON DOXORUBICIN CYTOTOXICITY IN CHEMORESISTANT MYELOMA CELL-LINES
TONG, AW
SU, D
ONO, K
STONE, MJ
[J]. BLOOD, 1993, 82 (10) : A260 - A260
[9] COMPARISON OF P-GLYCOPROTEIN EXPRESSION IN CELL-LINES AND XENOGRAFT SECTIONS USING I-125 MRK-16 MONOCLONAL-ANTIBODY (MAB)
MEHTA, BM
KOSTAKOGLU, L
LEVCHENKO, A
BROUSSARD, EL
DIVGI, CR
ZHANG, JJ
SCOTT, AM
FINN, RD
BIEDLER, JL
TSURUO, T
LARSON, SM
[J]. JOURNAL OF NUCLEAR MEDICINE, 1994, 35 (05) : P232 - P233
[10] MODULATION OF THE GROWTH OF HUMAN HEPATOCELLULAR CANCER XENOGRAFTS BY ANTI-P-GLYCOPROTEIN MONOCLONAL-ANTIBODY, MRK-16
LEVEILLE, CR
TSURO, T
ARIAS, IM
[J]. HEPATOLOGY, 1993, 18 (04) : A189 - A189

← 1 2 3 4 →