Cyclophosphamide-Induced Cardiomyopathy: A Case Report, Review, and Recommendations for Management

被引：101
|
作者：
Dhesi, Sumandeep [1 ]
Chu, Michael P. [1 ]
Blevins, Gregg [1 ]
Paterson, Ian [1 ]
Larratt, Loree [1 ]
Oudit, Gavin Y. [1 ]
Kim, Daniel H. [1 ]
机构：
[1] Univ Alberta, Edmonton, AB, Canada
来源：
JOURNAL OF INVESTIGATIVE MEDICINE HIGH IMPACT CASE REPORTS | 2013年 / 1卷 / 01期
关键词：
cyclophosphamide; cardiotoxicity; cardiomyopathy; myocarditis; heart failure; mechanical circulatory support;
D O I：
10.1177/2324709613480346
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Cyclophosphamide is increasingly used to treat various types of cancers and autoimmune conditions. Higher doses of this drug may produce significant cardiac toxicity, including fatal hemorrhagic myocarditis. In this review, we present a case of cyclophosphamide-induced cardiomyopathy requiring mechanical circulatory support. We also describe the pathophysiology, clinical manifestations, and risk factors for this important clinical entity and propose early detection and management strategies.
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页数：7
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