Between November 1982 and September 1991, 179 patients with unilateral or bilateral sixth nerve palsy were treated in the Botulinum Toxin Strabismus Clinic at Moorfields Eye Hospital. Indications for treatment included prophylaxis (as part of a prospective treatment trial), maintenance therapy, diagnosis and adjunct to surgical therapy. A management plan for established sixth nerve palsy based on the rational use of toxin and surgery is suggested.