COBALT BLOCKS L-GLUTAMATE-INDUCED APNEA AND ARTERIAL-HYPOTENSION IN THE NUCLEUS-TRACTUS-SOLITARII OF ANESTHETIZED RATS

被引：3
|
作者：
VITAGLIANO, S [1 ]
BERRINO, L [1 ]
PIZZIRUSSO, A [1 ]
LAMPA, E [1 ]
ROSSI, F [1 ]
机构：
[1] UNIV NAPLES 2,FAC MED & SURG,INST PHARMACOL & TOXICOL,I-80138 NAPLES,ITALY
来源：
NEUROPHARMACOLOGY | 1994年 / 33卷 / 01期
关键词：
NUCLEUS TRACTUS SOLITARII; L-GLUTAMATE; N-METHYL-D-ASPARTATE; COBALT;
D O I：
10.1016/0028-3908(94)90110-4
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The local application of cobalt reversibly blocks calcium-channel conductance and therefore synaptic transmission. In this study pretreatment with a solution of cobalt (100 mM) in the nucleus tractus solitarii (NTS) of anaesthetized rats significantly blocked the apnea (P < 0.01) and arterial hypotension induced by L-glutamate (25 mM) and N-methyl-D-aspartate (0.4 mM) microinjected in the NTS. We conclude that cobalt causes these effects by acting at the postsynaptic level.
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页码：145 / 146
页数：2
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