FACTORS THAT INFLUENCE THE SUPPRESSION OF PULMONARY ANTIBACTERIAL DEFENSES IN MICE EXPOSED TO OZONE

被引:40
|
作者
GILMOUR, MI [1 ]
PARK, P [1 ]
DOERFLER, D [1 ]
SELGRADE, MK [1 ]
机构
[1] UNIV N CAROLINA,CTR ENVIRONM MED & LUNG BIOL,CHAPEL HILL,NC 27514
关键词
D O I
10.3109/01902149309064348
中图分类号
R56 [呼吸系及胸部疾病];
学科分类号
摘要
Exposure to ozone (O3) has been shown to increase susceptibility of mice to bacterial infection; however, the underlying mechanism has not been well elucidated. This study investigated the effect of O3 exposure on the ability of mice to combat an infectious challenge of Streptococcus zooepidemicus. Following a 3-h exposure to either air, 0.4 ppm O3, or 0. 8 ppm O3, 5- and 9-week-old mice received an aerosol infection of bacteria. Intrapulmonary killing of the bacteria was impaired in the O3-exposed mice. The effect was most severe at the higher dose of O3 in the younger mice, and showed good correlation to subsequent mortality assessed over a 20-day period. Alveolar macrophages (AM) from O3-exposed mice bad an impaired ability to phagocytose the bacteria. Additionally, prostaglandin E2 (PGE2) levels, which are known to depress AM function, were increased in the bronchoalveolar lavage fluid of the younger mice following exposure to O3. while pretreatment with indomethacin in the drinking water blunted the increased of PGE2 and reduced O3 enhanced mortality from 53 to 33%. The data show that O3 inhalation can reduce the defensive capability of the murine lung and that this is associated with a reduction in AM phagocytosis. The defect is more marked in young mice, suggesting that they may be more susceptible to oxidant exposure. Further studies are required to distinguish between direct toxicity of O3 on the AM and indirect suppression due to modulation of pharmacologic or inflammatory mediators.
引用
收藏
页码:299 / 314
页数:16
相关论文
共 50 条
  • [1] Suppression of pulmonary antibacterial defenses mechanisms and lung damage in mice exposed to fluoride aerosol
    Yamamoto, S
    Katagiri, K
    Ando, M
    [J]. JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES, 2001, 62 (06): : 485 - 494
  • [2] Oxidized phospholipids impair pulmonary antibacterial defenses: Evidence in mice exposed to cigarette smoke
    Thimmulappa, Rajesh K.
    Gang, Xing
    Kim, Jung-Hyun
    Sussan, Thomas E.
    Witztum, Joseph L.
    Biswal, Shyam
    [J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2012, 426 (02) : 253 - 259
  • [3] AMINOPHYLLINE-INDUCED SUPPRESSION OF PULMONARY ANTIBACTERIAL DEFENSES
    NELSON, S
    SUMMER, WR
    JAKAB, GJ
    [J]. AMERICAN REVIEW OF RESPIRATORY DISEASE, 1985, 131 (06): : 923 - 927
  • [4] DEHYDRATION AND FACTORS AFFECTING PULMONARY ANTIBACTERIAL DEFENSES
    MULLANE, JF
    WILFONG, RG
    PHELPS, TO
    HUBER, GL
    [J]. JOURNAL OF SURGICAL RESEARCH, 1974, 16 (01) : 44 - 49
  • [5] BLOOD-LOSS AND FACTORS AFFECTING PULMONARY ANTIBACTERIAL DEFENSES
    ROTH, RR
    MULLANE, JF
    HUBER, GL
    PHELPS, TO
    WILFONG, RG
    [J]. JOURNAL OF SURGICAL RESEARCH, 1974, 17 (01) : 36 - 42
  • [6] EFFECTS OF ARSENIC TRIOXIDE INHALATION EXPOSURE ON PULMONARY ANTIBACTERIAL DEFENSES IN MICE
    ARANYI, C
    BRADOF, JN
    OSHEA, WJ
    GRAHAM, JA
    MILLER, FJ
    [J]. JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH, 1985, 15 (01): : 163 - 172
  • [7] RESPIRATORY AFLATOXICOSIS - SUPPRESSION OF PULMONARY AND SYSTEMIC HOST DEFENSES IN RATS AND MICE
    JAKAB, GJ
    HMIELESKI, RR
    ZARBA, A
    HEMENWAY, DR
    GROOPMAN, JD
    [J]. TOXICOLOGY AND APPLIED PHARMACOLOGY, 1994, 125 (02) : 198 - 205
  • [8] ENDOTOXIN-INDUCED SUPPRESSION OF PULMONARY ANTIBACTERIAL DEFENSES AGAINST STAPHYLOCOCCUS-AUREUS
    HARRIS, SE
    NELSON, S
    ASTRY, CL
    BAINTON, BG
    SUMMER, WR
    [J]. AMERICAN REVIEW OF RESPIRATORY DISEASE, 1988, 138 (06): : 1439 - 1443
  • [9] ERYTHROMYCIN-INDUCED SUPPRESSION OF PULMONARY ANTIBACTERIAL DEFENSES - A POTENTIAL MECHANISM OF SUPERINFECTION IN THE LUNG
    NELSON, S
    SUMMER, WR
    TERRY, PB
    WARR, GA
    JAKAB, GJ
    [J]. AMERICAN REVIEW OF RESPIRATORY DISEASE, 1987, 136 (05): : 1207 - 1212
  • [10] Modulation of pulmonary inflammatory responses and antimicrobial defenses in mice exposed to diesel exhaust
    Gowdy, Kymberly
    Krantz, Quentin T.
    Daniels, Mary
    Linak, William P.
    Jaspers, Ilona
    Gilmour, M. Ian
    [J]. TOXICOLOGY AND APPLIED PHARMACOLOGY, 2008, 229 (03) : 310 - 319