INHIBITION OF POLIOVIRUS RNA-SYNTHESIS BY BREFELDIN-A

被引：159
|
作者：
MAYNELL, LA
KIRKEGAARD, K
KLYMKOWSKY, MW
机构：
[1] UNIV COLORADO,MOLEC CELLULAR & DEV BIOL,BOULDER,CO 80309
[2] UNIV COLORADO,HOWARD HUGHES MED INST,BOULDER,CO 80309
来源：
JOURNAL OF VIROLOGY | 1992年 / 66卷 / 04期
关键词：
D O I：
10.1128/JVI.66.4.1985-1994.1992
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Brefeldin A (BFA), a fungal metabolite that blocks transport of newly synthesized proteins from the endoplasmic reticulum, was found to inhibit poliovirus replication 10(5)- to 10(6)-fold. BFA does not inhibit entry of poliovirus into the cell or translation of viral RNA. Poliovirus RNA synthesis, however, is completely inhibited by BFA. A specific class of membranous vesicles, with which the poliovirus replication complex is physically associated, is known to proliferate in poliovirus-infected cells. BFA may inhibit poliovirus replication by preventing the formation of these vesicles.
引用
收藏
页码：1985 / 1994
页数：10
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