DNA DAMAGE BY OXYGEN-DERIVED SPECIES - ITS MECHANISM AND MEASUREMENT IN MAMMALIAN SYSTEMS

被引：1321
|
作者：
HALLIWELL, B [1 ]
ARUOMA, OI [1 ]
机构：
[1] UNIV LONDON KINGS COLL, DEPT BIOCHEM, LONDON WC2R 2LS, ENGLAND
来源：
FEBS LETTERS | 1991年 / 281卷 / 1-2期
关键词：
DNA; MUTATION; OXYGEN RADICAL; HYDROXYL RADICAL; OXIDATIVE STRESS;
D O I：
10.1016/0014-5793(91)80347-6
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
When cells are exposed to oxidative stress, DNA damage frequently occurs. The molecular mechanisms causing this damage may include activation of nucleases and direct reaction of hydroxyl radicals with the DNA. Several oxygen-derived species can attack DNA, producing distinctive patterns of chemical modification. Observation of these patterns and measurement of some of the products formed has been used to determine the role of different oxygen-derived species in DNA cleavage reactions, to assess the extent of oxidative damage to DNA in vivo and to investigate the mechanism of DNA damage by ionizing radiation and chemical carcinogens.
引用
收藏
页码：9 / 19
页数：11
相关论文
共 50 条
  • [1] DNA DAMAGE INDUCED IN MAMMALIAN CELLS BY ACTIVE OXYGEN SPECIES
    郑荣梁
    A.A.LESKO
    P.O.P.TS’O
    Science in China,SerB., 1988, Ser.B.1988 (06) : 676 - 686
  • [2] DNA DAMAGE INDUCED IN MAMMALIAN-CELLS BY ACTIVE OXYGEN SPECIES
    ZHENG, RG
    LESKO, SA
    TSO, POP
    SCIENTIA SINICA SERIES B-CHEMICAL BIOLOGICAL AGRICULTURAL MEDICAL & EARTH SCIENCES, 1988, 31 (06) : 676 - 686
  • [3] Oxygen-derived free radicals as mediators of varicose vein wall damage
    Farbiszewski, R
    Glowinski, J
    MakarewiczPlonska, M
    Chwiecko, M
    Ostapowicz, R
    Glowinski, S
    VASCULAR SURGERY, 1996, 30 (01): : 47 - 52
  • [4] DNA DAMAGE AND OXYGEN SPECIES
    RUEFF, J
    LAIRES, A
    BRAS, A
    BORBA, H
    CHAVECA, T
    GASPAR, J
    RODRIGUES, A
    CRISTOVAO, L
    MONTEIRO, M
    DNA REPAIR MECHANISMS AND THEIR BIOLOGICAL IMPLICATIONS IN MAMMALIAN CELLS, 1989, 182 : 171 - 181
  • [5] THE MEASUREMENT OF OXYGEN-DERIVED FREE-RADICALS AND RELATED SUBSTANCES IN MEDICINE
    WEBER, GF
    JOURNAL OF CLINICAL CHEMISTRY AND CLINICAL BIOCHEMISTRY, 1990, 28 (09): : 569 - 603
  • [6] Oxygen and nitrogen are pro-carcinogens, Damage to DNA by reactive oxygen, chlorine and nitrogen species: measurement, mechanism and the effects of nutrition
    Halliwell, B
    MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS, 1999, 443 (1-2) : 37 - 52
  • [7] In vivo measurement of oxygen-derived free radicals during reperfusion injury
    Büttemeyer, R
    Philipp, AW
    Mall, JW
    Ge, BX
    Scheller, FW
    Lisdat, F
    MICROSURGERY, 2002, 22 (03) : 108 - 113
  • [8] THE CHEMICAL MODIFICATION OF GLYCOSAMINOGLYCAN STRUCTURE BY OXYGEN-DERIVED SPECIES IN-VITRO
    MOSELEY, R
    WADDINGTON, R
    EVANS, P
    HALLIWELL, B
    EMBERY, G
    BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 1995, 1244 (2-3): : 245 - 252
  • [9] OXYGEN-DERIVED FREE-RADICAL DAMAGE IN CANINE HEART-TRANSPLANTATION
    BANDO, K
    SENOO, Y
    JOURNAL OF SURGICAL RESEARCH, 1989, 46 (02) : 152 - 156
  • [10] Oxygen-derived free radicals as mediators of varicose vein wall damage - Discussion
    Perry, MO
    VASCULAR SURGERY, 1996, 30 (01): : 52 - 52
12345