IMMUNOHISTOCHEMICAL ANALYSIS OF RAT S-ADENOSYLMETHIONINE SYNTHETASE ISOZYMES IN DEVELOPMENTAL LIVER

被引：40

作者：

HORIKAWA, S ^{[1
]}

OZASA, H ^{[1
]}

OTA, K ^{[1
]}

TSUKADA, K ^{[1
]}

机构：

[1] TOKYO WOMENS MED COLL,CTR KIDNEY,SHINJUKU KU,TOKYO 162,JAPAN

来源：

FEBS LETTERS | 1993年 / 330卷 / 03期

关键词：

S-ADENOSYLMETHIONINE SYNTHETASE; ISOZYME; IMMUNOHISTOCHEMICAL ANALYSIS;

D O I：

10.1016/0014-5793(93)80894-Z

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Mammalian S-adenosylmethionine (AdoMet) synthetase exists as two isozymes, liver-type and kidney(non-hepatic)-type enzymes. The developmental expression of these two isozyme proteins has been investigated in rat liver using immunohistochemical techniques. The liver-type AdoMet synthetase is expressed only in adult liver, but not in fetal liver. On the other hand, the kidney-type AdoMet synthetase is predominantly expressed in fetal liver and faintly detected in adult liver. It was also found that both isozymes were localized to the hepatocytes of rat liver. These results clearly show that AdoMet synthetase isozymes are developmentally regulated within hepatocytes. In addition, in rat kidney we have shown that the kidney-type AdoMet synthetase is predominantly localized to the distal tubule.

引用

页码：307 / 311

页数：5

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