ANTIDEPRESSANT-LIKE EFFECT OF NEUROTENSIN ADMINISTERED IN THE VENTRAL TEGMENTAL AREA IN THE FORCED SWIMMING TEST

被引：19
|
作者：
CERVO, L
ROSSI, C
TATARCZYNSKA, E
SAMANIN, R
机构：
[1] MARIO NEGRI INST PHARMACOL RES, VIA ERITREA 62, I-20157 MILAN, ITALY
[2] POLISH ACAD SCI, INST PHARMACOL, PL-30060 KRAKOW, POLAND
来源：
PSYCHOPHARMACOLOGY | 1992年 / 109卷 / 03期
关键词：
NEUROTENSIN; DOPAMINE; MESOLIMBIC SYSTEM; ANTIDEPRESSANT ACTIVITY; RAT;
D O I：
10.1007/BF02245885
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Locomotor activity and behaviour in the forced swimming test were examined in rats which had received neurotensin (0.5-5.0 mug) in the ventral tegmental area. Doses of 5 mug neurotensin but not lower increased the locomotor activity for at least 2 h. At 0.5 and 1.0 mug neurotensin significantly increased the time the animals spent in struggling with no changes in general motor activity (swimming). The effect of 1.0 mug neurotensin on struggling was completely antagonized by 0.5 mug (-)sulpiride administered in the posterior nucleus accumbens. The results suggest that activation of the mesolimbic dopamine system through administration of neurotensin in the ventral tegmental area produces antidepressant-like effects. The significance of these findings for a role of endogenous neurotensin in depression remains to be clarified.
引用
收藏
页码：369 / 372
页数：4
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