The role and prognostic value of apoptosis in colorectal carcinoma

被引:26
|
作者
Alcaide, Julia [1 ]
Funez, Rafael [2 ]
Rueda, Antonio [1 ,3 ]
Perez-Ruiz, Elisabeth [1 ,3 ]
Pereda, Teresa [2 ]
Rodrigo, Isabel [2 ]
Covenas, Rafael [4 ]
Munoz, Miguel [4 ]
Redondo, Maximino [3 ,5 ]
机构
[1] A S Costa Sol, Onco Hematol Dept, Div Med Oncol, Malaga 29603, Spain
[2] A S Costa Sol, Dept Pathol, Malaga 29603, Spain
[3] Red Invest Serv Salud REDISSEC, Malaga, Spain
[4] Hosp Infantil Univ Virgen Rocio, Res Lab, Seville 41013, Spain
[5] Univ Malaga, A S Costa Sol, Res Unit, Malaga 29603, Spain
来源
BMC CLINICAL PATHOLOGY | 2013年 / 13卷
关键词
Apoptosis; Colorectal carcinoma; Prognosis;
D O I
10.1186/1472-6890-13-24
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background: Alterations to apoptosis are a common occurrence in human tumours. The aim of our study was to determine the influence of apoptotic variations on the carcinogenesis and prognosis of colorectal carcinomas (CRCs). Methods: A TUNEL assay was performed on archival material from 103 colorectal carcinomas, 26 adenomas and 20 samples of normal epithelia. Results: The number of apoptotic cells was higher in CRCs (1.09 +/- 0.13) than in adenomas (0.38 +/- 0.23, p = 0.059) and normal epithelium (0.06 +/- 0.04, p = 0.001). In addition, the apoptotic index (AI) was greater in metastatic disease (stage IV) than in other stages (p = 0.017). No relationship was found between apoptotic rates and age, gender or tumour grade. However, patients with tumours that showed higher AI values had a significantly lower disease-free survival (DFS) and overall survival (OS) than those with tumours that had lower AIs (p = 0.020 and p = 0.027). In a multivariate Cox proportional hazards model, AI remained a significant independent predictor of survival. Conclusions: We conclude that disregulated apoptosis is an important event during CRC development and progression. Higher AIs are associated with more aggressive tumours and a poorer prognosis for patients with CRC.
引用
收藏
页数:7
相关论文
共 50 条
  • [1] The role of apoptosis in colorectal carcinogenesis and its prognostic value.
    Alcaide, Julia
    Funez, Rafael
    Rueda, Antonio
    Perez-Ruiz, Elisabeth
    Pereda, Teresa
    Rodrigo, Isabel
    Perez, Diego
    Villatoro, Rosa
    Nogales, Esteban
    Redondo, Maximino
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 2013, 31 (15)
  • [2] Apoptosis as a prognostic factor in colorectal carcinoma
    Sugamura, K
    Makino, M
    Kaibara, N
    [J]. SURGERY TODAY-THE JAPANESE JOURNAL OF SURGERY, 1998, 28 (02): : 145 - 150
  • [3] Apoptosis as a Prognostic Factor in Colorectal Carcinoma
    Kenji Sugamura
    Masato Makino
    Nobuaki Kaibara
    [J]. Surgery Today, 1998, 28 : 145 - 150
  • [4] Prognostic value of prolactin in colorectal carcinoma - A case report
    Chauhan, A.
    [J]. ANNALS OF ONCOLOGY, 2008, 19 : I54 - I54
  • [5] PROGNOSTIC VALUE OF DNA ANALYSIS IN COLORECTAL-CARCINOMA
    BOTTGER, TC
    POTRATZ, D
    STOCKLE, M
    WELLEK, S
    KLUPP, J
    JUNGINGER, T
    [J]. CANCER, 1993, 72 (12) : 3579 - 3587
  • [6] PROGNOSTIC VALUE OF INTRATUMORAL NEUTROPHILS IN ADVANCED COLORECTAL CARCINOMA
    Kourelis, T.
    Tsamandas, A. C.
    Makatsoris, T.
    Bonikos, D.
    Kardamakis, D.
    Kalofonos, H. P.
    [J]. ANTICANCER RESEARCH, 2004, 24 (5D) : 3540 - 3541
  • [7] Prognostic value of DNA image cytometry in colorectal carcinoma
    Sampedro, A
    Urdiales, G
    MartinezNistal, A
    Riera, J
    Hardisson, D
    [J]. ANALYTICAL AND QUANTITATIVE CYTOLOGY AND HISTOLOGY, 1996, 18 (03): : 214 - 220
  • [8] Prognostic value of natural killer cells in colorectal carcinoma
    Helal, I.
    Ben Abdallah, K.
    Khanchel, F.
    Fkih, S.
    Hedhli, R.
    Ben Brahim, E.
    Jouini, R.
    Chadli, A.
    [J]. VIRCHOWS ARCHIV, 2022, 481 (SUPPL 1) : S97 - S98
  • [9] Inhibitors of Apoptosis Proteins Expression and Their Prognostic Significance in Colorectal Carcinoma
    Lee, Kyung-Hwa
    Lee, Soong
    Lee, Hyeon-Min
    Back, Seung-Chul
    Cho, Sung-Bum
    Lee, Jae-Hyuk
    [J]. KOREAN JOURNAL OF PATHOLOGY, 2011, 45 (04) : 397 - 405
  • [10] Prognostic value of micrometastases in esophageal and colorectal carcinoma -: (A clinical experience)
    Laso, CA
    González, JJ
    Fresno, F
    Azcano, E
    Sanz, L
    Navarrete, F
    [J]. HEPATO-GASTROENTEROLOGY, 2004, 51 (58) : 964 - 967