INVESTIGATION OF THE POSSIBLE INFLUENCE OF THE ABSORPTION OF VINPOCETINE WITH CONCOMITANT APPLICATION OF MAGNESIUM-ALUMINUM-HYDROXIDE GEL

The concomitant application of magnesium-aluminium-hydroxide gel does not influence the absorption of vinpocetine (CAS 42971-09-5). The pharmacokinetics of vinpocetine under the influence of a concomitant application of magnesium-aluminium-hydroxide gel was investigated. 18 healthy male volunteers were included in the study. Vinpocetine was administered in the galenic form of a film-coated tablet in a dosage of 20 mg t.i.d. over 10 days. On days 5 and 6 of the study, blood samples were taken at 16 different moments over 24 h and analyzed as to their vinpocetine content. Starting with the 6th day of the study, the patients were administered in addition 1 sachet of an magnesium-aluminium-hydroxide gel 4 times a day. On day 9 of the trial, blood samples were taken again over 24 h. The parameters examined were AUC, C(min), C(max), t(max) and Mean Residence Time. The results as to these parameters of day 5 were compared with those of day 9. As a further parameter, apovincaminic acid plasma levels were determined. There was no difference as to the vinpocetine amount absorbed with or without concomitant application of magnesium-aluminium-hydroxide gel. Apovincaminic acid plasma levels were lowered by approx. 11 % when associated with the antacid.