THE CAFFEINE CONTRACTURE TEST FOR MALIGNANT HYPERTHERMIA - CAFFEINE CITRATE, CAFFEINE BENZOATE OR CAFFEINE FREE BASE

被引：3
|
作者：
HEYTENS, L
HEFFRON, JJA
CAMU, F
机构：
[1] NATL UNIV IRELAND UNIV COLL CORK,DEPT BIOCHEM,CORK,IRELAND
[2] UNIV HOSP ANTWERP,DEPT INTENS CARE,ANTWERP,BELGIUM
[3] VRIJE UNIV BRUSSELS,DEPT ANAESTHESIA,B-1050 BRUSSELS,BELGIUM
来源：
ACTA ANAESTHESIOLOGICA SCANDINAVICA | 1991年 / 35卷 / 06期
关键词：
CAFFEINE; CONTRACTURE; MALIGNANT HYPERTHERMIA; MUSCLE;
D O I：
10.1111/j.1399-6576.1991.tb03344.x
中图分类号：
R614 [麻醉学];
学科分类号：
100217 ;
摘要：
The aim of the present study was to investigate whether the three different caffeine preparations - caffeine citrate, caffeine benzoate and the free base - used for in vitro diagnosis of malignant hyperthermia susceptibility - produced the same amount of contracture in rat diaphragm. At equimolar caffeine concentrations, the pure base generated more tension in the rat diaphragm muscle than caffeine benzoate or caffeine citrate. The citrate lowers the pH and the free Ca2+ concentration of the test bath and thus suppresses the caffeine contracture. The benzoate is believed to inhibit the caffeine contracture by its carbonyl group in a way similar to the effect of benzocaine.
引用
收藏
页码：541 / 544
页数：4
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