DISAPPEARANCE OF IMMUNE DEPOSITS WITH EDTA CHELATION-THERAPY IN A CASE OF IGA NEPHROPATHY

被引:9
|
作者
LIN, JL [1 ]
LIM, PS [1 ]
机构
[1] KUAN TIEN GEN HOSP,DIV NEPHROL,TAICHUNG,TAIWAN
关键词
IGA NEPHROPATHY; GOUT; LEAD; IMMUNE DEPOSITS; CHELATION;
D O I
10.1159/000168498
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
In this report, we describe the development of renal function impairment in a 33-year-old patient with mesangial IgA nephropathy and a history of recent gout. Increased body lead burden was identified with a positive EDTA mobilization test. The patient was treated with 1 g of edetate disodium calcium weekly for 2 months until normalization of urinary lead excretion. Improvement of renal function and proteinuria were noted. It was even more interesting to find that both immunofluorescence and electron microscopy studies of the second biopsy specimen revealed the loss of previous mesangial immune deposits. Our case demonstrated that lead may be a nonspecifically damaging factor related to the deterioration of renal function in patients with preexisting renal disease. Moreover, the disappearance of mesangial immune deposits after chelation therapy has not been previously documented. The pathogenetic basis of this observation is unknown, and its causal relationship with lead requires further elucidation.
引用
收藏
页码:457 / 460
页数:4
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