A NEO-DARWINIAN ALGORITHM - ASYMMETRICAL MUTATIONS DUE TO SEMICONSERVATIVE DNA-TYPE REPLICATION PROMOTE EVOLUTION

被引：34

作者：

WADA, K

DOI, H

TANAKA, S

WADA, Y

FURUSAWA, M

机构：

[1] RES DEV CORP JAPAN,ERATO,FURUSAWA MORPHOGENE PROJECT,2-5-2 NAGATA CHO,CHIYODA KU,TOKYO 100,JAPAN

[2] CHUKYO UNIV,SCH COMP & COGNIT SCI,TOYOTA 40703,JAPAN

[3] DAIICHI PHARMACEUT CO LTD,MOLEC BIOL RES LAB,EDOGAWA KU,TOKYO 134,JAPAN

[4] NIIGATA UNIV,SCH MED,NIIGATA 951,JAPAN

[5] FUJITSU LABS LTD,BIOL INFORMAT SECT,IIAS,MIHAMA KU,CHIBA 261,JAPAN

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1993年 / 90卷 / 24期

关键词：

D O I：

10.1073/pnas.90.24.11934

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Evolution is, in a sense, to resolve optimization problems. Our neo-Darwinian algorithm based on the mechanics of inheritance and natural selection uses double-stranded DNA-type genetic information to resolve the ''knapsack problem.'' The algorithm with asymmetrical mutations due to semiconservative DNA-type replication most effectively resolved the problem. Our results strongly suggest that disparity in mutations caused by the asymmetric machinery of DNA replication promotes evolution, in particular of diploid organisms with a high mutation rate, in a small population, and under strong selection pressure.

引用

页码：11934 / 11938

页数：5