The need for eco-regional or landscape-scale conservation and development has been widely recognised in Madagascar, yet implementation remains problematic. The approach was initially driven by biodiversity-conservation concerns, without enough emphasis on sustainable development, especially agriculture. Current challenges include consensus building for ecoregional visions, strengthening partnerships with government institutions, and negotiating land-use trade-offs within focal landscapes. Increased attention to revenue generation from agriculture and forest products, as well as enhanced communication and widespread participation by all stakeholders, should augment the success of broad-scale conservation and development programmes.