NEW CYCLIC-DERIVATIVES OF 3'-AMINO-3'-DEOXYADENOSINE-5'-DIPHOSPHATE, 3'-AMINO-3'-DEOXYADENOSINE-5'-TRIPHOSPHATE, AND 3'-AMINO-3'-DEOXYADENOSINE-5'-METHYLENEBIS(PHOSPHONATE)

A ten‐membered ring system forms part of the adenosine derivative 2, which can be prepared from triphosphate 1 by an intramolecular condensation with the water‐soluble carbodiimide l‐ethyl‐3‐(3‐dimethylaminopropyl)carbodiimide hydrochloride (EDC); analogous compounds with six‐ and eight‐membered ring systems are accessible from the corresponding mono‐ and diphosphates, respectively. Compounds of this kind are of interest, for instance, as potential enzyme inhibitors. A = adenyl. (Figure Presented.) Copyright © 1994 by VCH Verlagsgesellschaft mbH, Germany