STABILITY OF AN ORAL MIDAZOLAM SOLUTION FOR PREMEDICATION IN PEDIATRIC-PATIENTS

被引:0
|
作者
SOY, D [1 ]
LOPEZ, MC [1 ]
SALVADOR, L [1 ]
PARRA, L [1 ]
ROCA, M [1 ]
CHABAS, E [1 ]
CODINA, C [1 ]
MODAMIO, P [1 ]
MARINO, EL [1 ]
RIBAS, J [1 ]
机构
[1] UNIV BARCELONA,HOSP CLIN & PROVINCIAL,ANESTHESIOL SERV,BARCELONA,SPAIN
来源
PHARMACY WORLD & SCIENCE | 1994年 / 16卷 / 06期
关键词
DRUG COMPOUNDING; DRUG STABILITY; MIDAZOLAM ADMINISTRATION AND DOSAGE; PEDIATRICS;
D O I
暂无
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The objectives of this study were to assess the stability of a 1 mg/ml oral midazolam solution elaborated by our Hospital Pharmacy Service, and to confirm its clinical effect in pre-surgical paediatric patients. The solution's stability was tested by determining its pH and its UV-visible absorption spectrum at room temperature for up to 60 days. A high performance liquid chromatography method was used to confirm it. There was no significant change in pH value of either the test or a control solution. No loss of midazolam could be detected during the test. The Anaesthesiology Service assessed the sedation quality (very good, good, bad) and the venous puncture response, 20 minutes after the administration of 0.3 mg/kg of an oral midazolam solution. Twenty children were examined (age: 4-7 years). In addition, the haemodynamic and ventilatory functions were I evaluated.
引用
收藏
页码:260 / 264
页数:5
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