IMMUNITY TARGETING COMMON CORE ANTIGENS OF GRAM-NEGATIVE BACTERIA

被引：31

作者：

TYLER, JW

CULLOR, JS

SPIER, SJ

SMITH, BP

机构：

[1] Departments of Clinical Pathology, School of Veterinary Medicine, University of California at Davis, Davis, California

[2] Departments of Medicine, School of Veterinary Medicine, University of California at Davis, Davis, California

来源：

JOURNAL OF VETERINARY INTERNAL MEDICINE | 1990年 / 4卷 / 01期

关键词：

D O I：

10.1111/j.1939-1676.1990.tb00870.x

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

Antibodies against common gram‐negative core antigens can provide protection against environmental, commensual, and contagious bacteria that cause life‐threatening gram‐negative sepsis/endotoxemia. Cross‐protective immunity may be effective against many common livestock diseases, including neonatal coliform septicemia, coliform mastitis, septic metritis, and severe enteritis. The greatest potential benefit of cross‐protective immunity may be realized in the reduction of ill‐thrift and mortality of neonates. The use of active and passive immunization against core antigens common to gram‐negative bacteria has been successful in human beings, laboratory animals, and livestock. Protection has been observed following challenge with either heterologous endotoxin or unrelated, live, virulent gram‐negative bacteria. (Journal of Veterinary Internal Medicine 1990; 4:17–25) Copyright © 1990, Wiley Blackwell. All rights reserved

引用

页码：17 / 25

页数：9

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