SEVERE SKIN NECROSIS FOLLOWING WARFARIN THERAPY IN A PATIENT WITH PROTEIN-C DEFICIENCY

被引：13

作者：

LOCHT, H

LINDSTROM, FD

机构：

[1] Department of Medicine, Division of Rheumatology, University Hospital Linköping, Linköping

来源：

JOURNAL OF INTERNAL MEDICINE | 1993年 / 233卷 / 03期

关键词：

ANTICOAGULATION; PROTEIN-C DEFICIENCY; SKIN NECROSIS;

D O I：

10.1111/j.1365-2796.1993.tb00989.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A female patient with a history of both arterial and venous thrombosis developed extensive skin necrosis following warfarin treatment. When protein C deficiency was diagnosed, successful anticoagulation with warfarin was achieved by prolonging the course of intravenous heparin and introducing warfarin therapy with a low initial dose which was gradually increased. Aspects of the pathogenic mechanism are discussed.

引用

页码：287 / 289

页数：3

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