AN EFFECTIVE SYNTHESIS OF SCALEMIC 3,5,5-TRISUBSTITUTED PYRROLIN-4-ONES

被引：35
|
作者：
SMITH, AB
HOLCOMB, RC
GUZMAN, MC
KEENAN, TP
SPRENGELER, PA
HIRSCHMANN, R
机构：
[1] UNIV PENN,MONELL CHEM SENSES CTR,PHILADELPHIA,PA 19104
[2] UNIV PENN,CTR RES STRUCT MATTER,PHILADELPHIA,PA 19104
来源：
TETRAHEDRON LETTERS | 1993年 / 34卷 / 01期
关键词：
D O I：
10.1016/S0040-4039(00)60058-8
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A new two-step method employs the intramolecular cyclization of metalated imino esters for the construction of scalemic 3,5,5-trisubstituted pyrrolin-4-ones (4). The imino esters in turn derive from alpha-disubstituted amino acids, the latter readily available via a new protocol exploiting the enantioretentive alkylation of oxazolidinones.
引用
收藏
页码：63 / 66
页数：4
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