APOLIPOPROTEIN(A) PHENOTYPES IN DANES WITH AND WITHOUT CORONARY HEART-DISEASE

被引：0
|
作者：
LEMMING, L [1 ]
KLAUSEN, IC [1 ]
HANSEN, PS [1 ]
GERDES, LU [1 ]
FAERGEMAN, O [1 ]
机构：
[1] AARHUS UNIV,AARHUS KOMMUNE HOSP,DEPT INTERNAL MED & CARDIOL A,DK-8000 AARHUS C,DENMARK
来源：
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES | 1995年 / 5卷 / 03期
关键词：
LIPOPROTEIN; LIPOPROTEIN(A); CORONARY HEART DISEASE;
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
We have compared lipoprotein(a) (Lp(a)) concentrations and apoliprotein (a) (apo(a)) phenotypes in 101 Danish patients with ischemic heart disease (IHD) with those in 466 Danish reference subjects. The median Lp(a) concentration was significantly higher in IHD patients (19.0 mg/dl; 95% CI 14.4-26.4) than in reference men (6.33 mg/dl; 95% CI 5.5-7.3). The phenotype distribution in IHD patients and reference men was significantly different (p=0.00811) with higher frequencies of the apo(a) low molecular weight isoforms in IHD patients. This indicated that Lp(a) is a risk factor for IHD in a Danish population and supports the concept that alleles at the apo(a) gene locus predict the risk of IHD.
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收藏
页码：231 / 236
页数：6
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