ALCOHOL CAN INHIBIT EFFECT OF IL-4 ON ACTIVATED MURINE B-CELLS

被引：12
|
作者：
ALDOBENSON, M
PRATT, L
HARDWICK, J
机构：
[1] Division of Rheumatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, 46202-5103, IN, 541 Clinical Drive
来源：
IMMUNOLOGIC RESEARCH | 1992年 / 11卷 / 02期
关键词：
ETHANOL; IL-4; LYMPHOCYTE-B PROLIFERATION;
D O I：
10.1007/BF02918616
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Ethanol addition to B lymphocytes in vitro inhibits antigen-induced antibody secretion and antigen-induced cell proliferation. We tested the hypothesis that ethanol can inhibit the effect of interleukins on B-cell proliferation by adding ethanol to in vitro functional assays for IL-2 and IL-4. Ethanol does not inhibit IL-2-induced B-cell differentiation, but it does inhibit IL-4-induced B-cell proliferation and IL-4-induced Ig class switching.
引用
收藏
页码：117 / 124
页数：8
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