POSTNATAL CHANGE IN A CA-2+-MEDIATED DECREASE IN (NA+ + K+)-ATPASE ACTIVITY IN RAT-BRAIN SLICES

被引：8
|
作者：
MATSUDA, T [1 ]
SHIMIZU, I [1 ]
BABA, A [1 ]
机构：
[1] OSAKA UNIV,FAC PHARMACEUT SCI,DEPT PHARMACOL,1-6 YAMADA OKA,SUITA,OSAKA 565,JAPAN
来源：
BRAIN RESEARCH | 1992年 / 572卷 / 1-2期
关键词：
(NA+ + K+)-ADENOSINE TRIPHOSPHATASE; CA-2+; DEVELOPMENT; VERATRINE; MONENSIN; ISCHEMIA;
D O I：
10.1016/0006-8993(92)90499-Y
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The treatment of brain slices from immature rats with veratrine and monensin did not cause any change in (Na+ + K+)-adenosine triphosphatase (ATPase) activity or [H-3]ouabain binding in membranes prepared from the slices, though these reagents remarkably stimulated Ca2+ uptake in the slices. Exposure of the slices from adult rats to a glucose-free, hypoxic or both glucose-free and hypoxic medium resulted in a decrease in the enzyme activity, but the enzyme from immature rats was resistant to the conditions.
引用
收藏
页码：349 / 351
页数：3
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