BMY-7378 IS AN AGONIST AT 5-HT1A RECEPTORS MEDIATING HYPOTENSION AND RENAL SYMPATHO-INHIBITION IN ANESTHETIZED CATS

被引：17
|
作者：
STUBBS, CM
CONNOR, HE
FENIUK, W
机构：
来源：
EUROPEAN JOURNAL OF PHARMACOLOGY | 1991年 / 197卷 / 01期
关键词：
BMY-7378; 5-HT1A RECEPTOR AGONISTS; SYMPATHO-INHIBITION;
D O I：
10.1016/0014-2999(91)90373-X
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The putative 5-HT1A receptor antagonist BMY 7378 (3-100-mu-g . kg-1 i.v.) caused reductions in blood pressure, heart rate and efferent renal nerve activity in anaesthetised cats. Similar effects were produced by the selective 5-HT1A receptor agonist, 8-hydroxy-2(di-n-propylamino)tetralin (8-OH-DPAT 1-10-mu-g . kg-1 i.v.). The sympatho-inhibitory effects of BMY 7378 and 8-OH-DPAT, but not those of clonidine were reversed by the non-selective 5-HT1A receptor antagonist, spipirone (1 mg . kg-1 i.v.). It is concluded that BMY 7378 is an agonist at 5-HT1A receptors mediating hypotension and renal sympatho-inhibition in anaesthetised cats.
引用
收藏
页码：113 / 116
页数：4
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