CHEMOPREVENTIVE EFFICACY OF A BETEL LEAF EXTRACT AGAINST BENZO[A]PYRENE-INDUCED FORESTOMACH TUMORS IN MICE

被引：41
|
作者：
BHIDE, SV [1 ]
ZARIWALA, MBA [1 ]
AMONKAR, AJ [1 ]
AZUINE, MA [1 ]
机构：
[1] TATA MEM HOSP,CANC RES INST,BIOORGAN UNIT,BOMBAY 400012,INDIA
来源：
JOURNAL OF ETHNOPHARMACOLOGY | 1991年 / 34卷 / 2-3期
关键词：
BENZO[A]PYRENE; BETEL LEAF; CHEMOPREVENTION; FORESTOMACH TUMOR;
D O I：
10.1016/0378-8741(91)90039-G
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
The effect of betel leaf extract and some of its constituents, eugenol, hydroxychavicol, beta-carotene and alpha-tocopherol, on benzo[a]pyrene-induced foestomach neoplasia in male Swiss mice was examined. Betel leaf and its constituents decreased the number of papillomas per animal with the maximum protection, considering molar dosage, exhibited by beta-carotene and alpha-tocopherol. Except for beta-carotene, eugenol, hydroxychavicol and alpha-tocopherol increased the levels of reduced glutathione in the liver while glutathione S-transferase activity was enhanced by all except eugenol. Of seven sources, Banarasi betel leaves showed the maximum amounts of beta-carotene and alpha-tocopherol.
引用
收藏
页码：207 / 213
页数：7
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