No studies are available of spinal cord examination in cases of fluorotic spinal compression. Only one report in the literature is concerned with the spinal cord in a case of industrial fluorosis. The findings in this patient, who died of glioblastoma multiform, indicate the presence of anterior horn cell disease in fluorosis. In the present study, spinal cords in five fluorotic dogs from the endemic area were studied histologically: in none of the spinal cord sections was evidence of anterior horn cell lesion observed.