A NEW SYNTHESIS OF 2-SUBSTITUTED DL-TRYPTOPHAN DERIVATIVES

被引：0

作者：

BALSAMINI, C ^{[1
]}

DIAMANTINI, G ^{[1
]}

DURANTI, A ^{[1
]}

SPADONI, G ^{[1
]}

TONTINI, A ^{[1
]}

机构：

[1] UNIV URBINO,IST CHIM FARMACEUT & TOSSICOL,I-61029 URBINO,ITALY

来源：

SYNTHESIS-STUTTGART | 1995年 / 04期

关键词：

DEHYDROAMINO ACIDS; INDOLES; MICHAEL-TYPE ADDITION; 2-SUBSTITUTED TRYPTOPHANS; 2-BROMOTRYPTOPHAN SYNTHESIS;

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Methyl 2-substituted N-(diphenylmethylene)-DL-tryptophanates were prepared by means of Lewis acid catalysed Michael-type addition of methyl N-(diphenylmethylene)dehydroalaninate to suitable 2-substituted indoles. Hydrolysis of these tryptophan derivatives affords the corresponding amino acids. Examples of selective deprotection of either the amino or carboxylic group are reported.

引用

页码：370 / 372

页数：3

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