The Underappreciated Role of the Humoral Immune System and B Cells in Tumorigenesis and Cancer Therapeutics: A Review

被引：6

作者：

Chen, Victor E. ^{[1
,2
]}

Greenberger, Benjamin A. ^{[1
,2
]}

Taylor, James M. ^{[1
,2
]}

Edelman, Martin J. ^{[3
]}

Lu, Bo ^{[1
,2
]}

机构：

[1] Thomas Jefferson Univ, Dept Radiat Oncol, Sidney Kimmel Med Coll, Philadelphia, PA 19107 USA

[2] Thomas Jefferson Univ, Ctr Canc, Philadelphia, PA 19107 USA

[3] Fox Chase Canc Ctr, Dept Hematol Oncol, 7701 Burholme Ave, Philadelphia, PA 19111 USA

来源：

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS | 2020年 / 108卷 / 01期

关键词：

TERTIARY LYMPHOID STRUCTURES; T-CELLS; RADIATION IMPLICATIONS; ANTITUMOR RESPONSES; IONIZING-RADIATION; DENDRITIC CELLS; ANTIBODIES; TUMORS; RADIOTHERAPY; PHENOTYPE;

D O I：

10.1016/j.ijrobp.2020.03.022

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The advent of immunotherapy has ushered in a new era in both cancer research and cancer treatment strategies. Published reviews have described potential mechanisms for therapeutic synergisms from the combination of radiation therapy and immunotherapy, largely overlooking the role of humoral immunity by only focusing on cellular immunity. Given that these 2 branches of the immune system are highly interdependent, in this review we detail both what has already been established regarding the role of humoral immunity in cancer and propose potential avenues that are ripe for further investigation and potential clinical applications. (C) 2020 Elsevier Inc. All rights reserved.

引用

页码：38 / 45

页数：8

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