DIETHYLENE GLYCOL (DEG)-ASSOCIATED MYOCARDIAL CHANGES - A PILOT INVESTIGATION OF CHRONIC INTOXICATION IN GUINEA-PIGS

The myocardium of guinea pigs fed on sublethal doses of diethylene glycol (DEG) over a period of 2-11 days was examined for microscopical and ultrastructural changes. Coagulative myocytolysis and loss of myofibrils, not observed in the controls, was patchily distributed throughout the myocardium. The accompanying ultrastructural features included swelling, pleomorphism and hyperplasia of mitochondria with an associated distension of the interfibrillary spaces and a displacement, distortion and rupture of adjacent myofibrils.